Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination

Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B cells that diversifies effector component of antibody responses. CSR initiated by activity cell-specific enzyme activation-induced cytidine deaminase (AID), which leads to formation programmed DNA double-strand breaks (DSBs) at Ig heavy chain (Igh) locus. Mature use a multilayered and complex regulatory framework ensure AID-induced are channeled into productive repair reactions leading CSR, avoid aberrant events causing lymphomagenic chromosomal translocations. Here, we review pathways acting on DSBs their functional interplay, with particular focus latest developments molecular composition mechanistic regulation.